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Selective inhibition of selenocysteine tRNA maturation and selenoprotein synthesis in transgenic mice expressing isopentenyladenosine-deficient selenocysteine tRNA

However, in humans the data is contradictory

SLU-PP-332: the non-peptide agonist SLU-PP-332 illustrates the second strategy

It arrived sooner than expected

As Frontiers in Endocrinology (2023) confirmed: "Most known selenoproteins, such as glutathione peroxidase, are expressed in the thyroid and are involved in thyroid hormone metabolism, redox state regulation, and maintenance of cellular homeostasis." In other words, selenium's documented benefits for Hashimoto's thyroiditis are mechanistically dependent on adequate glutathione availability